AB0160 THE RELATIONSHIP BETWEEN THE LEVEL OF FETUIN-A AND LABORATORY MARKERS OF CONNECTIVE TISSUE DESTRUCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS

Background It is known that there are biochemical markers of cartilage and bone tissue destruction, which reflect the metabolic processes occurring in tissues. For example, rheumatoid arthritis (RA), routine such as CTX-I, a degradation marker (C-terminal telopeptide type I collagen) CTX-II, II collagen), can be used. Also, to assess state tissue, determination collagen fragments by Urine CartiLaps widely used, allows not only primary diagnosis, but also dynamic monitoring processes. Objectives The aim our research was study relationship between level fetuin-A (FeA) laboratory blood serum patients with RA. Methods We observed 110 verified diagnosis RA, control group consisted 30 practically healthy individuals without joint diseases. RA were comparable terms age (p=0.083), gender (p=0.116), BMI (p=0.302). based on clinical classification adopted at EULAR/ACR 2010. FeA determined once enzyme immunoassay using commercial test systems (Human Fetuin-A ELISA Biovender Cat No. 191-0371). Results have assessed donors. normal FA individuals, calculated M±2σ, ranged from 653.55 µg/ml 972.19 µg/ml. normally distributed (K-S d=0.062, p>0.2). studied indicators metabolism concentration FeA. In levels (n=87), mean CTX-1 35 ng/mL; reduced (n=23), 51 ng/ml (t=-2.42 p =0.016). Thus, decrease level, CTX-I (an indicator osteodestruction) tended increase. Next, we analyzed low Cartilaps/urine creatinine ratio intragroup analysis methods. Cartilaps/urinary 598.9±223.72 µg/mmol versus 481.17±226.93 (Z=-2.311; p=0.021). Our data probably allow us associate rate destruction. Conclusion Considering Cartilaps statistically lower presence an elevated FeA, conclude has chondro- osteoprotective properties. assumed this used predict destruction issue requires further study. Disclosure Interests None declared